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Rox Factor IX                                                               CE 

REF 900020

In Vitro Diagnostic Use (Europe)

In Vitro Research Use Only (Outside Europe)

For determination of Factor IX activity in plasma and Factor IX preparations, including potency assignment of FIX concentrates.

- A chromogenic kit based upon FXa generation.

- 1 Kit = 2 x 50 test

- No use of FIX deficiency plasma

- Detection Limit: 0.1% FIX (CLSI EP17-A)

- Quantification Limit: 0.5% FIX (CLSI EP17-A)

- Linearity: 0.5 - 200% (CLSI EP06-A)

Measurement Principle

FIX is activated by human FXIa with concomitant activation of  human FX by generated FIXa in the presence of FVIII, calcium ions and phospholipids. The amount of formed FXa is related to the FIX activity and is measured through hydrolysis of a chromogenic FXa substrate. There is no use of FIX deficiency plasma. The Kit contains a fibrin polymerization inhibitor and a heparin antagonist.

Features of the Rox Factor IX kit were presented on a poster at the ISTH 2011 meeting in Kyoto. (Since then bovine FXIa has been substituted with human FXIa, read more here):



2016-06-22 Publication in collaboration with NovoNordisk

Rosén P, Rosén S, Ezban M, Persson E.

Overestimation of N-glycoPEGylated factor IX activity in one-stage factor IX clotting assay owing to silica-mediated premature conversion to activated factor IX.

J Thromb Haemost 2016; 14: 1420-7.


2016-05-23 Steffen Rosén, Rossix will hold a presentation at the SSC meeting in Montpellier.

Title : New Tools to Study Contact Activation
Session : Factor XI and the Contact System
Room : Barthez
Date : 27-05-2016


2016-05-23 Pia Bryngelhed, Rossix will present a poster at the SSC meeting in Montpellier.

Poster FVIII-49:

Application of Rox Factor IX on the ACL TOP 700


2015-04-13 Publication in collaboration with AstraZeneca

Ann Lövgren et al. Blood Coagulation and Fibrinolysis, Characterization of thrombin derived from 

human recombinant prothrombin.

Open access: click here


2014-11-13 ECAT meeting 2014 - Leiden, NL

Steffen Rosén, Rossix held a presentation titled

How to measure low levels of Factor VIII and IX


2014-06-18  Rox Factor IX - CE

The Rox Factor IX kit for determination of Factor IX activity is approved for In Vitro Diagnostic Use in Europe.

Learn more >>